Genetic karyotyping-inozivikanwawo seyokuongorora chromosome-kuedza kunogona kuratidza mamwe maitiro ekusaremara. Inogona kushandiswa kusimbisa kana kuongorora chirwere chemajini kana zvirwere. Kana, kuedza kunogona kuratidza kuti vaviri vari panjodzi yekuva nemwana ane chirwere chegeneti kana chromosomal disorder.
Semuenzaniso, karyotyping inogona kuratidza kuti mukomana ane mukomana ane Klinefelter syndrome, chirwere che genetic chinowanzosati chaongororwa kusvikira murume achinetseka .
Varume vane Klinefelter syndrome vane imwe yero X chromosome muDNA yavo (pane kungova XY chete vari XXY), uye ivo vanowanzoshaya vana.
Chiremba wako anogona kukurudzira genetic karyotyping kana:
- Iwe hauna kukwanisa kubata pamuviri kwegore rinopfuura .
- Iwe wakamboona maviri kana kupfuura zvakatevedzana zvisingabatsiri.
- Wakawana kuberekwa patsva.
- Mukadzi ane mukomana haavi nemhando mumumvuri wake kana kuti mbeu yakaderera zvikuru. (Iyo inozivikanwawo kuti azoospermia kana yakaoma oligozoospermia.)
- Mudzimai wechikadzi akaonekwa kuti ane chirwere chekutanga chekuvhara maitiro. (Inowanziwo sePPI, inotanga kuvhara mavari , kana POF, kukanganisa kusati kwapera.)
Genetic karyotyping inogona kudiwa musati mawana rubatsiro rwekuberekera vana, kusanganisira IUI kana IVF. Izvi zvinonyanya kukosha kune avo vanofunga IVF ne ICSI , iyo inowedzera mukana wekupfuura kushaya simba kwevarume uye zvimwe zvirwere zvepabonde.
Muedzo Unoitwa Sei?
Kune vakaroorana vasina kuberekwa, muedzo unowanzoitwa kuburikidza neropa rinodhonza, kubva kune vose varume nevakadzi.
Ropa samples rinoshandiswa mubazi.
Masero kubva murapa yeropa akaiswa mune imwe chigadziko chakanaka kuti avakurudzire kukura. Kamwe masero acho paanosvika pane imwe nhanho yekukura, masero anotasvibiswa uye akadzidziswa pasi microscope.
Bhizimisi rebazi vanoongorora masero emasero uye chimiro. Vanotorawo mifananidzo yemasero uye vanoverenga nhamba yekromosomes mumasero.
Iyo mifananidzo yakajeka inoita kuti urongwa hwechromosome huongororwe.
Chikonzero nei Kupa Mazano Okuberekwa Kunogona Kukurudzirwa Pamberi Pekuchirapa Kurapa
Kuongorora mazino kunogona kuwana chikonzero chekuberekwa kwako kana kurasikirwa kwakawedzerwa. Kuziva kuti sei iwe usingakwanisi kutora pamuviri, kana kuti sei uchiramba uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge waita.
Chimwe chikonzero chekuita mazita ekuongorora mazita asati aita kurapa ndeyekudzivisa kupfuurira pakukanganisa kuberekwa kwemazamu kune mwana weramangwana.
Zvimwe zvipenyu zvinoshanduka zvinogona kukonzera kusununguka kana zviripo mumubereki mumwe chete, asi, kana vabereki vose vakatakura kuchinja, vanogona kupa mwana wavo chinonyanya kukosha chimiro chechimiro.
Semuenzaniso, CFTR gene mutation inobatanidza nemamwe marudzi ehurume husina simba. Inosanganisirawo chirwere chakakomba, cystic fibrosis.
Kana baba chete vane CFTR gene mutation, kune ngozi yekudarika kushaya mwana kumwana wake. Kana vose baba naamai vari vatakuri veCFTR gene mutation, kune 1 mu4 mukana vachave nemwana ane cystic fibrosis.
Kana vaviri vari kutarisa IVF ne ICSI, njodzi yekupfuurira maitiro ezvepamusoro kune yakakura kupfuura iyo inowanzoitwa IVF kana kuti kubata pamuviri.
Izvi ndezvokuti neVIV nguva dzose, mbeu inogadzirirwa mune petri dish nezai, uye "yakasimba" mbeu yepamusoro inopinda.
NeAVF-ICSI, chirume chimwe chete chinosarudzwa uye chinorirwa zvakananga muzai. Izvo zvinokonzerwa ne "genetically" simba "mbeu" iyo inosanganisa mazai yakawanda kwazvo mumamiriro ezvinhu aya. Izvi zvinokonzera njodzi yekudarika mamwe matambudziko emagetsi.
Sarudzo Kana Iwe Une High Genetic Risk
Zvisarudzo zvako zvichange zvichitarira pane zvinokonzerwa nehutano huri kutarisana nayo.
Mune zvimwe zviitiko, kuongororwa kwegeneti chinokonzera kana njodzi inogona ...
- kusimbisa kana kubatsira kubatsira kunyanya kushaya zvirwere
- kuwedzera kungozi yako yekuparara kana kuberekwa
- kuwedzera mukana wako wokuva nemwana ane chirwere chakasiyana-siyana chema genetic
- kuwedzera mungozi yako yekudarika mwana wako kana mukadzi kusununguka kumwana wako
A genetic counselor anofanirwa kuongorora zviwanikwa zvako newe.
Kazhinji kutaura kwako, zvingasarudzwa zvinogona kusanganisira chero ipi zvayo inotevera:
Wedzera preimplantation genetic diagnosis (PGD ) kumushonga wako weVF. NePGD, inenge ichikudziridza mucheche ine kero imwechete yakabviswa kuti iongorore maitiro ekuchinja. (Kubvisa kero iri hakukuvadzi embryo.) Mishonga inotarisa yakareba inogona kuendeswa.
Vaya vane zviremera zvemafuro - vazhinji vavo vangave vasina kumbopona-vakarasa.
PGD inogona kuderedza ngozi yekuparara kwepakutanga uye inogona kuderedza ngozi yehumwe hutachiona hwemafuro. Asi kunyange nePGD, pamuviri nemwana hazvivimbiswi kuva 100% maitiro ehutano. Iwe unogona kunge uchingokuvhiringidza kunyange nePGD.
Vamwe vane tsika kana zvechitendero vanopesana nePGD kuedza.
Sarudza kutendera IVF-ICSI . Kazhinji, kana mazai nehuta zvakabatanidzwa pamwe chete, hupenyu huri hutano hunoita kuti hupinde uye hutunga mazai. Kusarudzwa kwezvakasikwa kunopedza simba rakashata, iro rinogonawo kuva nemuviri unokanganisa.
NeAVF ne ICSI, chirume chinopindwa zvakananga muzai. Sarudzo yakasikwa haigone kuitika. Izvi zvinogona kuwedzera mungozi yekupfuurira kuchinja kwemajini.
Unogona kusarudza kusatora ngozi uye kudzivisa IVF-ICSI. Pane kudaro, iwe unogona ...
- Edzai nguva dzose IVF (kunyange zvazvo inogona kunge yakaderera kubudirira iwe)
- rega kurapwa
- Sarudza chirume kana embryo mupiro panzvimbo
Ramba uchirapa , usingaregi kuwedzera kungozi yekupfuura chimiro chechimiro kana kushaya mwana mwana wako.
Kuva pangozi yekudarika mamiriro ezvinhu haisi chivimbo iwe ucha .
Taura kune mazita ekugadzira mazita kuitira kuti iwe uite chisarudzo chakanaka.
Sarudza kushandisa mushonga wemhara, egg donor, kana mubereki wemukomana. Zvechokwadi, kunyange kupa vanamatoti gametes vanogona kutakura genetic matambudziko. Vapegi vanowanzoongororwa, asi hapana sarudzo haisi pangozi.
Kana iwe uri kusarudza zamai kana kuti murume wemupepeti, zvakakosha uyo anopa mupiro anoongororwa nehutachiona huri pangozi yekupfuura.
Tsvaka kururamiswa kana hupenyu husina mwana. Mushure mokugamuchira zvibereko zvekuongorora zvirwere, vamwe vakaroorana vanosarudza kutora. Vamwe vanosarudza kurega kuedza kuva nemwana uye kurarama hupenyu hwemwana.
Kufungidzira Kwemangwana neGentic Counseling
Kuwana mitezo yegenetic karyotyping inogona kuva nemweya uye yakaoma.
Dzimwe nguva, zvigumisiro zvinogona kukubatsira kuti uite zvisarudzo pamusoro pekurapa kwako. Dzimwe nguva, hapana zvakawanda zvingaitwa nemashoko. Izvi zvinogona kukonzera kushushikana mupfungwa, pasina chikonzero chaicho.
Zvitendero zvako zvinogonawo kugadzirisa kuti kubatsira mazano ekuberekwa kuchave kwauri sei.
Zvakakosha iwe unonzwisisa kuti chii chine ruzivo rwema genetic counseling chichakupa iwe uye iwe unogona here kutora mairi usati waenda kuburikidza nekuedza.
Usati wabvumirana kuedza, bvunza kuti utaure neine mazita ekupa mazita. Vanogona kutsanangura zvinowedzera uye zvakanyanya zvekuedza uye vanokubatsira kuti uone kana kuedza kunonzwisisika iwe newawakaroorana naye.
Uyewo, iva nechokwadi chokuti pachava nemupi wezvemajini anowanikwa kuti ataure chero mhinduro.
Sources:
CFTR: Genesisi. Genetics Home Reference. Http://ghr.nlm.nih.gov/gene/CFTR
Cystic Fibrosis: Kuchechera Kuchechera uye Kuziva. FAQ171, February 2016. ACOG.org. Yakasvika musi waFebruary 18, 2016. http://www.acog.org/Patients/FAQs/Cystic-Fibrosis-Prenatal-Screening-and-Diagnosis
Dohle GR1, Halley DJ, Van Hemel JO, van den Ouwel AM, Pieters MH, Weber RF, Govaerts LC. "Zvirwere zvinokonzerwa nehutachiona muvarume vasina simba vane oligozoospermia uye azoospermia." Hum Kudzorerwa. 2002 Jan; 17 (1): 13-6.
Pamberi, Carlo; Ferlin, Alberto; Gianaroli, Luca; Dallapiccola, Bruno. " Mazano ekushandiswa kwakakodzera kwemajini ekuedza muvana vasingabatsiri. " European Journal of Human Genetics . May 2002, Bhuku 10, Nhamba 5, Mapeji 303-312.
Karyotyping. MedLine Plus. http://www.nlm.nih.gov/medlineplus/ency/article/003935.htm
Klinefelter syndrome. MedLine Plus. http://www.nlm.nih.gov/medlineplus/ency/article/000382.htm
Otani T1, Roche M, Mizuike M, Colls P, Escudero T, Munné S. "Preimplantation genetic diagnosis inovandudza zvikuru kuberekwa kwemigumisiro yevatakuri vemagetsi uye nhoroondo yekusununguka kwemazuva ose uye kutora mimba isina kubudirira." Reprod Biomed Online . 2006 Dec; 13 (6): 869-74. http://www.rbmojournal.com/article/S1472-6483(10)61037-1/abstract
Rubio C1, Simón C, Vidal F, Rodrigo L, Pehlivan T, Remohí J, Pellicer A. "Chromosomal kusagadzikana uye kukura kwechibereko mumakumbo akaroorana." Hum Reprod . 2003 Jan; 18 (1): 182-8.