Gonadotropin Side Effects for Fertility

Njodzi nemigumisiro yechirwere yeHemenicable Fertility Drugs

Usati watanga kurapwa ne gonadotropin - dzimwe nguva inonzi injectables - chiremba wako anofanira kukutsanangurira zvingava nemigumisiro uye njodzi dzokurapa. Iwe unogona kunge uchitora gonadotropin pamwe chete naClomid , ivo pachavo, sechikamu cheIUI , kana sechikamu chekuvhara kweVIV .

Gonadotropin inoshandiswa zvakare kuvakadzi kupa mazai avo uye mazai echando .

Mazhinji gonadotropin migumisiro ine unyoro, asi muzviitiko zvisingawanzoitiki, zvimwe zvinogona kuva zvakakomba uye kunyange kutyisa upenyu.

Nyaya inokosha! Hazviiti zvose zvinokonzerwa nemigumisiro uye njodzi dzakanyorwa pasi apa. Kana uri kutarisana nemigumisiro yakakomba, zviratidzo zvisingawanzoiti, kana unonetseka nechikonzero chero chipi zvacho, taura nachiremba wako. Mashoko aya ari munyaya ino haaiti nzvimbo yekubvunzurudza nevhidhiyo.

Ndeapi Mishonga Inofungidzirwa Gonadotropins?

Gonadotropins imishonga inobereka ine FSH, LH , kana kusanganiswa kwemaviri (ayo anonzi menopausal gonadotropins, kana hMG). Zvinosanganisirawo hormone hCG , iyo inokanganisa biochemically yakafanana neHH.

Aya mahomoni anotorwa nejojo.

Gonadotropin inogona kubudiswa mumabhati achishandisa DNA recombinant , kana inogona kubudiswa uye kucheneswa kubva mumugodhi wevakadzi vanotora kana vane pamuviri.

Mazita emagetsi eti gonadotropins akasika kushandisa recombinant DNA teknolojia inosanganisira Gonal-F (rFSH), Follistim (rFSH), Puregon (rFSH), Luveris (rLH), uye Ovidrel (rHCG).

Bravelle, Metrodin, uye Fertinex ndiwo mazita emagetsi ekuvhenekera akabudiswa FSH.

Novarel, Pregnyl, naPasi ndivo urinary yakabudiswa hCG.

Mazita emagetsi ekuvhenekerwa kwevanhu manopausal gonadotropins (musanganiswa weFSH neLH) anosanganisira Humegon, Menogon, Pergonal, Repronex, uye Menopur.

Migumisiro Yechipfuva yeGonadotropins

Cherechedza: Zvikamu zviri pasi zvinoreva kutsvakurudza kuenzanisa Gonal-F - iyo iRFSH, yakagadzirwa mubazi kuburikidza nekombiki yeDNA teknolojia - uye urofollitropin, kana uFSH, yakanatswa FSH yakabviswa kubva mumugodhi wevakadzi ve postmenopausal. Mari inogona kusiyanisa zvishoma kubva kune zvinodhaka kusvika kune zvinodhaka, asi gonadotropin mishonga yemigumisiro inowanzofanana.

Zvinokonzerwa nemigumisiro yegonadotropin inosanganisira:

• Musoro (rFSH: 22%, uFSH: 20.2%)
• Nausea (rFSH: 13.6%, uFSH: 3.5%)
• Kumusoro kuputika kwepamuviri (infection) (rFSH: 11.9%, uFSH: 7.9%)
• Mucheche (rFSH: 9.3%, uFSH: 12.3%)
• Gesi (rFSH: 6.8%, uFSH: 8.8%)
• Sinus kusanganiswa (rFSH: 5.1%, FFSH: 5.3%)
• Kukurukurirana kukuru (rFSH: 5.9%, uFSH: 6.1%)
• Mafungiro anoshandura (rFSH: 5.1%, uFSH: 2.6%)
• Acne (rFSH: 4.2%, uFSH: 2.6%)
• Chirwere chepabonde (rFSH: 4.2%, uFSH: 6.1%)
• Kuwedzera kwehuwandu (rFSH: 3.6%, uFSH: 0.0%)
• Utachiona husina kunaka (rFSH: 2.5%, uFSH: 6.1%)
• Kubuda ropa kusina kuchena kana kuonekwa (rFSH: 2.5%, uFSH: 0.9%)
• Kuvhiringidza (rFSH: 2.5%, uFSH: 2.6%)
• Injection site pain, redness (rFSH: 2.5%, uFSH: 0.9%)
• Chizivi (rFSH: 2.5%, uFSH: 0.0%)

Ngozi dzeGonadotropins

Ovarian Hyperstimulation Syndrome (OHSS) : OHSS inowanikwa apo maevari uye mimba zvinovhiringidza nemvura. Kusvikira pa10 kusvika ku20% yevakadzi vacharamba vaine hunyoro hweHSSSS, iyo inowanzogadzirisa pachayo pachayo. Zvakakosha kuzivisa kunyange zviratidzo zvishoma kune chiremba wako, saka anogona kunyatsocherechedza iwe.

Kana uine PCOS , iwe uri pangozi yakawanda yekukura kweHSSSS.

HSSSS yakanyanya inowanikwa muzasi pe1% yevarwere. Bvunza chiremba wako pakarepo kana iwe uine kurutsira, kurwadziwa kwepamuviri kana kurwadziwa kweplavic, kukurumidza kuwedzerwa kuwedzera, kana kuputika kukuru.

• OHSS Zviratidzo uye Kurapa

Kubata pamuviri : Kubva pane zvidzidzo zvaunotarisa, muwandu wezvipembenene nemishonga yegonadotropin kune chero ipi zvayo kubva pa2% kusvika ku30%, uye kusvika kusvika ku5% triplet kana kupfuura yakakura yekuita.

Zvirwere zvemakemikari zvakawana kuti vazhinji vane pamuviri vanoitika 12 kusvika ku14% yenguva iyo pavanoshandisa rFSH kana uFSH zvakaenzana. Kunyatsotarisa uye kushandiswa kwechirwere chinonyanyobudirira kunogona kuderedza ngozi.

Paunoshandisa gonadotropin panguva yeIUI kana yoga, zvakanyanya kuoma kuti uchengetedze njodzi yezvipembenene kupfuura iyo yakashandiswa panguva yeVIV. Munguva yeVIV, chiremba wako anogona kutora imwe yembryo.

Kana iwe uine hanya pamusoro pengozi yewanda, uye iwe uri kushandisa injectable sechikamu cheIUI purogiramu, unogona kuda kubvunza chiremba wako nezve mini-IVF .

• Dambudziko reKubata pamuviri kune Amai neMucheche

Ovarian cysts : Ovarian cysts inowanzoitika ne gonadotropins. NeRFSH, inowanikwa anenge 15% yenguva yacho, uye neUFSH inowanikwa ne29% yenguva.

Kazhinji, vanogadzirisa voga. Muzviitiko zvisingawanzoiti, zvingada kupinda muuropi.

Kuipa kwechirwere chetachiona : Humwe hutsvuku uye unyoro hwakajairika, asi mune zvisingawanzoitika, nzvimbo yejojo ​​inogona kutapukirwa. Bvunza chiremba wako kana iwe uchicherechedza pane nzvimbo yejojo ​​inowedzera kubwinya, kupisa nguva dzose, kupfugama, pfu, kunhuhwirira, kana kurwadziwa kukuru. Uyezve, kana ukawana fevhiri kupfuura 101, taura nachiremba wako.

Adnexal torsion (kana ovarian twisting) : Muzviitiko zvisingawanzo (zvishoma kupfuura 2% yenguva), chirwere chinogona kuchinja, kuputika, kana kubuda ropa, zvinoda kupindira. Izvi zvinowanzoitika nokuti ovary inorema uye yakawedzerwa kubva pakukurudzira.

Ectopic pregnancy : Ngozi ye ectopic pregnancy inowedzera kuwedzera paunotora gonadotropin. Ectopic pregnancy zvinogona kutyisidzira upenyu kana kuti zvingada kupinda mukati.

Ropa rakavhara : Zvikuru zvisingawanzovi (4.2 kubva ku1 000) asi zvinogona kutyisidzira upenyu.

Kuwedzera kweropa rekuvhara ropa hakusi munguva yekurapa, asi, kana iwe uchitora pamuviri, unoramba uchikwirira munguva yekuzvitakura.

Kana iwe uine zviratidzo zvekugona kweropa ropa-kuvhara kana kurwadziwa gumbo rimwe, kudziya munzvimbo yakakanganiswa, kuchinja kweganda reganda (redness, bluish, kana kuti panya) - taura nachiremba wako pakarepo.

Kana iwe ukatanga zviratidzo zveprommoni embolism - kamwe-kamwe kusuruvara kwekufema, kurwadziwa kwepfupa kunowedzera kana iwe uchiedza kutora kufema kwakanyanya kana kana iwe uchikandira, uchinzwa mvere dzisina simba kana kuti kushaya simba, kukurumidza kukurumidza, kuputika, kukonzera ropa, pfungwa kuparadzwa kuri kuuya - kuwana rubatsiro rwechirwere pakarepo.

> Sources

_{Gonal-f (follitropin alfa yejojo). Drug information sheet. http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20378scf015_gonal_lbl.pdf}

_{Henriksson P, Westerlund E, Wallén H, Brandt L, Hovatta O, Ekbom A. "Kuitika kweplummum and thongembolism in veous in pregnancy after in vitro fertilization: cross-sectional study." BMJ. 2013 Jan 15; 346: e8632. doi: 10.1136 / bmj.e8632. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546085/}

_{Migumisiro Yakashata yeGonadotropins: Mwoyo Murefu Chikafu. American Society for Reproductive Medicine.}