Chii chinonzi Metformin, Zvimwe Zvinobudirira Pakupedzisira, uye Nei Inoshandiswa Kuita Infertility
Metformin iyi inonzi insulin-senitizing drug inoshandiswa zvikuru kurapa chirwere cheshuga, asi inogona kushandiswawo kubereka. Vakadzi vane PCOS vanogona kubatsirwa nokutora metformin voga, pamwe chete neComomid, kana kunyange panguva yehutano hweVIV. Zvakananga kuti metformin inovandudza sei kubereka hairi pachena.
Kunyange zvazvo metformin inogona kushandiswa mukurapa kwekusabereka , haisi mishonga yekubereka.
Kutaura zvazviri, kushandiswa kwaro kubata kurapwa kunofungidzirwa kusati kwave kushandiswa. (Mune mamwe mazwi, kubudirira pamuviri hakusi yepakutanga chinangwa chechirwere ichi.)
Chii ichi mishonga? Uye ingakubatsira sei kubata?
Chii Chinonzi Metformin?
Kuti unzwisise zvinonzi metformin, iwe kutanga unoda kuziva kuti insulin inopikisa chii. Vakadzi vazhinji vane PCOS vane insulin yekudzivirira. Insulin kushorwa ndiyo apo masero emumuviri anoramba achiita kune maitiro akaenzana e insulin. Vanoita zvishoma, kana kusagadzikana.
Somugumisiro, muviri unofunga kuti hakuna insulin yakakwana mumutambo. Izvi zvinokonzera kugadzirwa kwe insulin yakawanda kupfuura muviri wako unoda.
Ikoko kunoratidzika kuva nekubatana pakati pe insulini uye mahomoni ekubereka. Kunyange zvazvo pasina munhu ane chokwadi chaizvoizvo kuti vaviri vanobatana sei, insulin maitiro anotaridzika kutungamirira kuwedzera mazinga e androgens.
Varume nevakadzi vane androgens, asi androgens inowanzofungidzirwa se "mahomoni evanhu." High androgen levels inotungamirira kuPCOS zviratidzo uye zvinetso nehuvhu.
Metformin nemamwe mishonga inogadzirisisa insulini yakaderera muzinga re insulin mumuviri. Kunze kwe metformin, rosiglitazone uye pioglitazone mamwe insulini-kukurapa zvinodhaka zvinogona kushandiswa kurapa PCOS.
Nei Chirevo cheMetformin Chakashandiswa Kubata PCOS?
Pane zvikonzero zvakawanda nei chiremba wako achigona kuraira metformin apo iwe unoporesa PCOS yako, vamwe vavo vanobatana nekuberekana:
Insulin Resistance
Sezvakataurwa pamusoro, insulin kudzivisa inowanzoonekwa nevakadzi vane PCOS.
Metformin inogona kurairwa kuti irape kushandiswa kwekuchengetedzeka, izvo zvingabva zvabatsira kutonga mahomoni ekuberekwa uye kutangazve mavhinga.
Ovulation Induction
Imwe tsvakurudzo pamusoro pemetrafini nePCOS inoratidza kuti miviri inotora nguva yakawanda uye ovulation inodzoka nekurapa metformin. Izvi zvinogona kuitika kunze kwekuda mishonga yekuberekwa yakadai seClomid .
Zvisinei, dzimwe dzidzo dzakawanda dzitsvakurudzo dzakasawana kubatsirwa kutora metformin.
Nokuda kwechikonzero ichi, vamwe vanachiremba vari kurumbidza kuti metformin inoshandiswa kungobata vakadzi vane insulini-vasingagoni uye kwete vose vakadzi vane PCOS zvisinei pasinei nokuti ivo havaiti here.
Clomid Resistance
Apo Clomid ichatsigira vakadzi vakawanda neCPOS vachivhiringidza, vamwe vakadzi vane Clomid-resistant . (Iyi inzira inofadza yekureva kuti haina kubashandira.)
Dzimwe tsvakurudzo dzekutsvakurudza dzakaona kuti kutora metformin kwemwedzi 4 kusvika ku 6 isati yatanga chirwere cheCommid chinogona kubudirira kubudirira kwevakadzi vane Clomid-resistant.
Imwe nzira yevakadzi vane Clomid kushorwa inogona kuva metformin yakabatana ne letrozole .
Utachiona husingawaniki Utachiona
Kana Clomid isingakubatsiri kutora pamuviri, danho rinotevera rinowanzova gonadotropins kana mishonga inoberekwa inoberekwa .
Kutsvakurudza kwakawana kuti kusanganiswa kwejekesheni ine metformin kunogona kuwedzera huripo huripo hwekurera.
Chimwe chidzidzo chakawana kuti kubatanidza metformin nejaija kwakagadzirisa kuzvarwa kwekurarama hupenyu kana kuchienzaniswa nekurapa nemishonga chete. Muchidzidzo chino, kana kuberekwa kwemazuva ega nemajekiseni ari oga aiva 27 muzana, kurapwa ne metformin uye injectables kunowedzera hupenyu hwekurarama huri kusvika kusvika 32 kusvika ku60 muzana.
Nengozi Yakaderedza Ovarian Hyperstimulation Syndrome
Ovarian hyperstimulation syndrome (OHSS) inogona kuisa panjodzi pakushandisa zvinodhaka, kunyanya panguva yekurapa kweVIV. Vakadzi vane PCOS vane dambudziko rakanyanya kukura reHSSSS.
Zvimwe zvidzidzo zvakawana kuti metformin inogona kuderedza dambudziko reHSSSS munguva yeVIV. Zvisinei, hazvisi pachena kana OHSS yakaderedzwa kune dzimwe mishonga. Somuenzaniso, kutsvakurudza pamusoro pegonadotropins ndoga (pasina IVF) haina kuwana mutsauko mune OHSS mutengo paunowedzera metformin kune protocol yekurapa.
Kudzokorora Kudzingwa
Vakadzi vane PCOS vangangodaro vaine hupombwe kupfuura huwandu hwevanhu. Metformin inogona kuderedza dambudziko rekusununguka pamuviri kune vakadzi neCPOS, maererano nezvimwe zvidzidzo.
Zvidzidzo zvishomanana zvakawana kuti kupfuurira kwemasformin kurapwa munguva yekutanga kwekutora pamuviri kunogonawo kubatsira kudzivirira kupererwa kwevakadzi mune PCOS.
Zvisinei, kuchengetedzwa kwemasformin panguva yekuzvitakura hakusi kunyatsoratidzwa. Kusarudza kutora metformin panguva yekuzvitakura ingozi iyo inofanira kunyatsokurukurwa nechiremba wako.
Kurasikirwa Kwemafuro
PCOS inobatanidzwa nokuneta. Kukumanikidzwa kwevakadzi vazhinji, kuperevedza neCPOS kunogona kunge kwakaoma.
Zvimwe zvidzidzo zvakaratidza kuti metformin inogona kubatsira vakadzi neCPOS kurasikirwa. Sezvo kurasikirwa kwave kuchiratidzwa kuti kubatsire kugovera hutano uye kusvika pakuita pamuviri, chiremba wako anogona kutumira metformin, pamwe nechirongwa chekudya uye chiito chekuita muviri, kubatsira kubatsiridza kubereka kwako.
Chii Chiri Mhinduro Dzakashata?
Metformin inowanzovhiringidza nayo inokonzera kushungurudza mudumbu, kazhinji kuora, asi dzimwe nguva nekurutsa uye kusuruvara. Kutora metformin pakati pekudya kungabatsira kuderedza izvi.
Kuchengetedza kwakagadzikana nemigumisiro inogona kuderedza nguva. Vamwe vakadzi vanoona kuti zvimwe zvikafu zvinokonzera kushungurudzika kwesimba kupfuura vamwe.
Mamwe matambudziko makuru anowanzobatanidzwa ne metformin ane chiropa kusagadzikana uye inowanikwa asi isina simba, yakashata, lactic acidosis.
Paunenge uchitora metformin, chiremba wako anofanira kutarisa itsvo yako uye chiropa zvinoshanda. Vanhu vane mwoyo, chiropa, tsvete, kana chirwere chepapu havafaniri kutora metformin. Iva nechokwadi chekupa chiremba wako nezvenhoroondo yezvechiremba.
Kushandisa metformin kubata chirwere chinopesana neCPOS kuchiri kutsvakurudzwa, uye vanachiremba vakasiyana vane maonero anopikisa kana, kana, uye nzira yekushandisa metformin kubata sei kusununguka.
Usatya kutaurira zvinetso zvako uye mibvunzo kune wako anotarisira, kuitira kuti pamwe, iwe unogona kusarudza kana kurapwa uku kuri kwauri.
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