PGD nePGS: Genetic Screening Pamberi kweVIVF

by Rachel Gurevich; Yakadzokororwa naAnita Sadaty, MD

Preimplantation Genetic Screening Kudzivirira Denda uye Kuvandudza IVF Mufaro

Maitiro eGenetic screening akaita sePGD nePGS, kana akabatanidzwa nehutano hweVIV , akaita kuti zvikwanise kuderedza ngozi yekupfuura zvirwere zvinokonzera kuparadza, zvichida kuderedza dambudziko rekusimbiswa kwemazuva ose, uye zvichida kugadzirisa matambudziko ekudzivirira kubata pamuviri .

Sezvo nevose vakabatsira pakuberekwa kwekombiki, zvinokosha kuti unzwisise mamiriro ezvinhu iyo teknolojia inoshandiswa zvakanakisisa, zvinogona kuitika, mari, uye chii chaunotarisira munguva yekurapa.

Iwe unogona kuona mazwi echiPGD nePGS anoshandiswa zvakasiyana. Izvo zvose magetsi ekuongorora magetsi uye zvose zvinoda IVF, asi dzakasiyana chaizvo mukuti nei uye kuti dzinoshandiswa sei.

Chii chinonzi PGD?

PGD inomirira "preimplantation genetic diagnosis." Iko shoko guru pano ndi "kuongororwa."

PGS inoshandiswa apo imwe chaiyo (kana kuti yakatemwa) chirwere chinonzi genetic inofanira kuonekwa mumumbryo . Izvi zvinogona kudiwa kuti usapfuurira kune chirwere chetachiona kana kushandiswa kusarudza chimiro chaiyo chemazwi. Dzimwe nguva, zvose zvinodiwa-somuenzaniso, kana vaviri vachida kubata mwana anokwanisa kuenzaniswa ne stem cell transplant kune mukoma wako asiwo anoda kuti arege kupfuurira kune jeni rinokonzera chirwere ichi chinoda shina chekushandiswa kwepini.

PGD haina kuedza imwe yembryo yezvose zvinokonzerwa nehutachiona. Izvi zvakakosha kunzwisisa. Saka, somuenzaniso, kana mucheche usingaoneki une geni re cystic fibrosis (CF), izvo hazvina kukuudza chero chinhu chipi nechipi chinokonzerwa nehutachiona hunogona kuvapo.

Iyo inongokupa husimbiso kuti CF haigoni kunyanya.

Chii chinonzi PGS?

PGS inomirira "preimplantation genetic screening." PGS haina kutsvaga maitiro ega asi inotarisa kromosomal yakawanda inoumba embryo.

Embryo inogona kunyanya kusarudzwa seye euploidy kana aneuploidy . Mune mamiriro ezvinhu akajairika, zamai inobatsira ma chromosomes 23 uye chirume chimwe 23.

Pamwe chete, vanoumba hutano hwakanaka nema 46 chromosomes. Izvi zvinonzi "embroid embryo".

Zvisinei, kana mucheche ane chromosome yakawedzerwa-kana kuti haasisina chromosome-inonzi aneuploidy. Aneuploidy embryo inowanzokundikana kuisa kana kupera mukuparara. Kana kuiswa mimba, pamuviri, uye kuberekwa kuitika, aneuploidy mazai angaita kuti mwana ave nekuremara mupfungwa kana mumuviri.

Semuenzaniso, Down Syndrome inogona kuitika kana pane imwe yero yechromosome 18 kana 21. PGS inogona kuziva izvi zvisati zvaitika kuti embryo ishandiswe muchibereko. Mune zvimwe zviitiko, PGS inogona kuziva hutachiona hwemazwi emwana.

Kakawanda Chromosome Screening (CCS) ndiyo imwe nzira yePGS iyo inogona kuziva kana embryo iri XX (yevakadzi) kana XY (varume.) Izvi zvingashandiswa kudzivisa chirwere chinokonzerwa nehutano hwepabonde kana (kazhinji kazhinji) kuitira kuenzanisa kwemhuri.

Ko PGD / PGS uye kuongorora kwepabonde zvakasiyana sei?

Zvose zviviri PGD nePGS zvinowanikwa panguva yekutanga . Izvi zvakasiyana nekuedzwa kwepabonde, uko kusimwa kwatoitika. Kuongororwa kwepabonde kunogona kuitika chete kana pamuviri wakagadzirwa.

Chorionic villus sampling (CVS) uye amniocentesis inogona kuziva chromosomal kusagadzikana mumusikana asina kuberekwa. Kana kusakanganiswa kunofungidzirwa panguva yekuedzwa kwepabonde, zvingasarudzwa ndezvekuti kubvumira kuberekwa kuenderere kana kugumisa.

Izvi zvinogona kuva chisarudzo chakaoma kuita.

Vaya vanosarudza kuramba vachiita pamuviri vanotarisana nekusava nechokwadi uye kutya kwezvichauya pakuberekwa. Kunze kwekutya pamusoro pokuva nemwana ane hurema hwehupenyu hwose, vangasangana nehuwandu hwekuzvarwa. Vaya vanosarudza kubvisa pamuviri vanotambudzika, zvichida vane mhosva, uye kurwadziwa kwepanyama nekudzorerwa kubvisa pamuviri.

Uyezve, vamwe vanhu vane zvekunamata kana zvekuteerera kwepamuviri pakupera kwekuita pamuviri, asi vanonzwa vakasununguka nemararamiro ekuongorora vasati vasvika. Izvozvo zvakati, PGD nePGS hazvibvumirwi. Vanazhinji vanachiremba vanorayira kuedza kushandiswa kwepabonde kunze kwePGD / PGS, kungofanana kana chiitiko chekuongorora chikafu chakanga chakakanganisa kana chakanga chisisipo.

Zvikonzero Zvingaitika zvekuongororwa kweZvizivikanwa Zvekuberekwa Kwemagetsi NeVFF

Heano zvikonzero zvinogoneka chiremba wako angakurudzira PGD (kana zvikonzero zvaunogona kukumbira.)

Kuti urege kupfuurira pane chirwere chinokonzerwa nehutachiona chinotanga mumhuri : Ichi ndicho chikonzero chinowanzoitika chePGD. Zvichienderana nokuti chirwere chinokonzerwa nehutachiona chinotakura kana kuti chinoderedza, dambudziko rekupfuurira chirwere chetachiona kumwana chinogona kuva pakati pe25 ne50 muzana.

Mune zvimwe zviitiko, vakaroorana vangave vasati vashandise IVF kuti vawane pamuviri, uye vangave vasina kutarisana nekushaya simba. Chikonzero chavo choga chokutsvaga IVF chingave chekuongorora kwePGD.

Sezvataurwa pamusoro apa, kuedzwa kwepabonde kunogonawo kuedza zvirwere zvema genetic, pasina mari yakawedzerwa, njodzi, uye mari yekurapa kweVF. Asi sezvo chisarudzo choga chine kubvisa pamuviri (kana kuramba uchiita pamuviri) mushure mokunge uchitarisa pamuviri, izvi hazvigamuchirwi kune vamwe vakaroorana.

Kune mazana ezvirwere zvegeneti izvo zvinogona kuongororwa, asi zvimwe zvezvinowanzo ndezvi:

Cystic fibrosis
Tay-Sachs
Aneta-X
Muscular dystrophy
Sickle-cell anemia
Hemophilia
Simba remusana (atomphy muscle) (SMA)
Fanconi's Anemia

Kuchengetedza translocation kana chromosomal rearrangements : Vamwe vanhu vanoberekerwa nemakromosomes ose makumi mana, asi rimwe kana akawanda haasi munzvimbo inotarisirwa. Vanhu ava vangave vasina hutano hwakanaka, asi hutano hwavo hwekushaya vana, kuva nepamuviri kunokonzera kuora pamuviri kana kuberekwa, kana kuva nemwana ane chromosomal kusina kuwanda kwakakwirira kudarika zviyero.

Kune vakaroorana vane shamwari pamwe nekutumira , PGD inogona kushandiswa kubatsira kubatsira mazai akawanda kuti ave noutano hwakanaka.

Kuvanhu rinonzi leukocyte antigen (HLA) rinofananidza, ne stem-cell transplant : Stem-cell transplant ndiyo chete chirwere chezvirwere zveropa. Kuwana mukana mukati memhuri hakusi nyore nguva dzose. Zvisinei, PGD inogona kushandiswa kusarudza mucheche wekuti vaviri vari vaviri vachave se-stem-cell match (HLA match) uye zvichida kuti vasapfuurira kupfurikidza nechimwe chirwere chetachiona chinosangana nehanzvadzi.

Kana mwana achiri mucheche anogona kuonekwa kuti ndeye kufanana kweHLA, uye kuberekwa uye kuberekwa kwakanaka kunoitika, masero ekudzivirira anodiwa kuchengetedza hupenyu hwehanzvadzi inogona kuunganidzwa kubva mumbilical cord ropa pakuberekwa.

Kudzivisa kupfuurira kune chimiro chechimiro chechirwere chevanhu vakuru : Kushandiswa kwepfungwa kudukuka kwePGD ndechokudzivisa kupfurikidza nemafungiro emagetsi anogona kuunza zvirwere munguva inotevera muupenyu.

Somuenzaniso, BRCA-1 kenza yemazamu yemazamu. Kuva nejeni iri hazvirevi kuti munhu achange aine kenza yemvere, asi njodzi yavo yakakwirira. PGD inogona kushandiswa kuratidza mazai emhando yakasiyana ye BRCA-1. Mimwe mienzaniso inosanganisira chirwere cheHuntington uye chirwere chekutanga cheAlzheimer.

Zvinokwanisika Zvikonzero zveGeneral Genetic Screening (PGS / CCS) neVIV

Heano zvimwe zvikonzero zvinozivikanwa PGS inogona kushandiswa neVF treatment.

Kuvandudza mararamiro ekubudirira nekusarudza mushure mokuberekwa kwemukomana : Tsvakurudzo dzinoverengeka dzakaona kuti PGS inogona kubatsira kuvandudza matambudziko ekudzivirira nekuderedza dambudziko rekusununguka pamuviri, pakusarudza kusarudza imwe yemubereki kutengesa.

Nekusarudza kushandiswa kwemashure embryo kuendesa, kana eSET , chiremba wako anotumira imwe chete yehutano hunoona hutano mukati mehutano hweVIV . Izvi pane kuendesa mazai maviri kamwe chete, nzira inowedzera mikana yekubudirira asi inotakurawo mukana wekutora mawanda. Kuwanda kwepamuviri kunounza matambudziko kune utano nehutano hwevana.

Pasina PGS, iyo embryo yakasarudzwa zvichienderana nekuonekwa kwayo. Yakawanikwa, zvisinei, kuti mazamu asingaoneki akakwana pasi pe microscope anogona chaizvoizvo kuva ane utano. Uye mazai anoita sehutano angave asina kufanana nechromosomally sezvaanoonekwa. PGS inotora zvimwe zvekufungidzira kunze.

Kuziva mararamiro evanhu : Kazhinji inoshandiswa apo chirwere chetachiona chinotarisana nemadzimai, PGS inogona kubatsira kuziva kana mucheche ari mukadzi kana murume. Iyi inogona kunge iri nzira shoma shoma yekudzivirira chirwere chinoshandiswa pakuwedzera kupfuura PGD.

Zvisinei, PGS inogona kushandiswawo kubatsira vakaroorana vane mwana wehutano hwakanaka apo vanotarisira "kuenzanisa" mhuri yavo. Mune mamwe mazwi, vatove nemukomana uye iye zvino vanoda musikana, kana zvimwewo. Izvi zvaisawanzoitika kana vaviri vacho vasina kutoda IVF pane chimwe chikonzero.

Kutaura zvazviri, ASRM neAmerican College yezvipfeko uye Gynecologists (ACOG) zvinopesana nekushandisa PGS mukusarudza zvepabonde pasina chikonzero chekurapa.

Kuchengetedza njodzi yekupererwa pamuviri kuvakadzi vane nhoroondo yekurasikirwa kwekudzivirira pamuviri zvakare : Kuparadzana kwakajairika, kunoitika kusvika kusvika 25 kubva muzana yekubata pamuviri. Kudzokorora kwemazuva mashoma-kunopera katatu kana kupfuura kurasikirwa mumutsara-hausi. PGS inogona kushandiswa kubatsira kubatsira kuderedza kukanganisa kweimwe kusununguka.

Tsvakurudzo yekuti kana kwete PGS inogona kuvandudza matambudziko ekuzvimirira kuvakadzi vane nhoroondo yekudzivirirwa kwekudzivirira pamuviri haisi pachena. Kune vakaroorana vane musikana ane chromosomal translocation, kana chirwere chinonzi genetic chinowedzera njodzi yekudzivirira pamuviri kana kuberekwa, PGD (kwete PGS) inogona kuve yakananga.

Zvisinei, kune vakaroorana avo kurasikirwa kwavo kusingabatanidzi maitiro chaiwo ekudzivirira pamuviri, kana IVF nePGS chaizvoizvo zvinogona kuwedzera mikana yekuberekwa kurarama kupi zvese kunze kwekuramba uchiedza zvakajeka hazvisi pachena. Ikoko kunogona kunge kune mukana wakaderera wekutora pamuviri, asi kuberekwa kwakanaka uye kuberekwa hakugone kuuya nokukurumidza.

Parizvino, America Society of Reproductive Medicine haina kukurudzira IVF nePGS kuti inorapa kupererwa kwemazuva ose.

Kuvandudza matambudziko ekuzvitakura kubudirira kweVIV vachengeti : Vamwe vanoita vanachiremba vanokurudzira PGS pamwe neVF kuti vawedzere kunetseka kwehutano hwehutano hwehutano mumamiriro ezvinhu ehutachiona hunokonzera kusagadzikana , vakaroorana avo vakambosangana kakawanda kweVF kuumbwa kwekukundikana, kana vakadzi vezera remakore vakakurumbira . Mamwe makiriniki anopa PGS neVIV kuvarwere vose.

Ikozvino pane tsvakurudzo shomanana kuratidza kuti PGS ichavandudza kubudirira kwehutano hweVF kana isina kunyatsoratidzwa. Ongororo dzakawanda dzakawana hukuru hwekubudirira huri kutarisa hupenyu huripo huri hutano hwekuberekwa-uye kwete purogiramu. Izvi zvicharamba zvichikwirira kudarika mhiri yemitengo, nokuti haisi yega yeVFF inotora mazai kuti aende. Zvakaoma kuziva kana kune mukana wechokwadi. Zvimwe zvidzidzo zvinoda kuitwa.

Mazai Akaitwa Sei?

Kuti uite chero mazita ekuongorora mazita, masero anobva kumubhedha anofanira kunge akaitwa biopsied. Iyo zona pellucida ibhokisi rinodzivirira iro rinoputira embryo. Uyu hutete hwekudzivirira hunofanira kuputswa kuitira kuti uwane mamwe masero. Kuti ibudirire, an embryologist angashandisa laser, acid, kana girasi nenyano.

Pane imwe nguva sarudzo shoma yakaitwa, masero ekuedzwa anobviswa kana achitsva kuburikidza ne pipette, kana embryo inonyatsonyatsomiswa kusvikira masero mashomanana achibuda kuburikidza nekuvhurika kwakavhurika.

Bhupi ye embryo inogona kuitwa mazuva matatu mushure mekuberekwa kana mazuva mashanu. Pane hunobudirira uye hutsinye kune umwe neumwe.

Zuva 3 Embryo Biopsy : An embryo paZuva 3 inozivikanwa se blastomere. Inongova nemasero matanhatu kusvika mapfumbamwe. Zvinokwanisika kuita maitiro ekugadzirwa kwemashoko pane imwe kero, asi kutora zviviri zviri nani.

Chimwe chezvakanakisa zvikuru zvekuita Zuva 3 bhiopsy kuongororwa kunogona kuitwa munguva yekutsvaira kwema embroyo musi weSvondo 5 mushure mokutora mazai evha. Izvi zvinoreva nguva shomanana yekumirira uye kuderedza mari (sezvo iwe ungasafanira kubhadhara firimu yekushandiswa kwemazamu.)

Zvisinei, kumwe kutsvakurudza kwakawana kuti biopsy yeinopfuura imwe kero pazera iri inowedzera dambudziko re "embryo kukasungwa." Imbryo inogona kumira kusimba uye haigoni kuchinjwa. Izvi hazvishamisi, asi zvichiri ngozi yekufunga. Uyewo, njodzi yezvipo zvenhema nemigumisiro inobatanidza yakawanda neZuva 3 bhiopsy.

Zuva 5 Embryo Biopsy : Zuva 5 Embryo inonzi blastocyst. Panguva ino, embryo ine mazana emasero. Zvimwe zvemasero aya zvichava fetus, zvimwe zvikamu. Iyo embryologist inogona kutora mamwe masero ekuedza-kazhinji kutora pakati pe5 ne8-iyo inogona kubvumira kuti uwane hutano hwakanaka uye zvishoma zvisingagoneki mhinduro. Masero akatorwa ndeaakagadzirirwa kuva placenta; iyo fetal cells inosara isina kuonekwa.

Kukanganisa kweZuva rechipiri bhizinesi ndechokuti haasi mazai ose anoramba ari mumugadziri webasa kwemazuva mazhinji, kunyange mamwe mazai ane utano.

Uyewo, Zuva re5 biopsy inoda kuti embryos ichengetedzwe kusvikira mhinduro idzoka. Izvi zvinoreva kuti mukadzi achafanira kumirira kusvikira mwedzi unotevera kuti aite kuendeswa kwema embryo. Ichange chiri chando chemafremu yekufambisa. Izvi zvinoreva nguva yakareba yekumirira uye mari yakawedzerwa. Ikoko kunewo njodzi yokuti mazamu haazopona mazhenje uye nenyuchi.

Kunyange zvakadaro, mazamu akasimba chete anowanzosigara mushure mekuita izvi. Avo vanopona uye vane zvibereko zvakanaka zvePGS zvakanyanya kunyanya kutungamirira kumigumisiro yakanaka.

Ndeipi nzira yeVIV nePGD nePGS?

Kune dzimwe misiyano muhutano hwehuwandu hwehutano hwe IVF hunoenda sei kuPGD kana PGS kuedza.

Chokutanga pane zvose, nePGD, iyo inogona kutanga mwedzi yakawanda isati yaitwa chaiyo yekurapa IVF. Zvichienderana nehutano chaihwo hutachiwana hunoda, kuongorora mazita emhuri kunogona kudiwa. Izvi zvinodikanwa kuti zvigadzire purogiramu yegene, iyo inofanana nemepu inoshandiswa kufungidzira chaiyo apo maitiro asina kufanira kana kuti chiratidzo chiri.

PGS haina kudikanwa kuongorora maitiro edzimhuri uye inosanganisira kuongorora mazamu. Munguva yechokwadi chaiyo yeVF, chiitiko chevarwere chePGS nePGD zvakafanana, kunyange zvazvo ruzivo rwezvemagetsi huri kuitika mubhizi rwakasiyana. Kana iwe usingazivi nezvekodzero yemakirini eVF asi, verenga nhanho-nhanho tsanangudzo yekutanga.

Ikoko IVF ine maitiro ekugadzirisa maitiro akasiyana-siyana akasiyana nehutano huri pahutachiona. Kazhinji, mushure mekuberekwa, mazai ane hutano anofanirwa kutaridzirwa kutengesa mazuva matatu kana mashanu mushure mokutora mazai. Ne PGS kana PGD, mazai aya anonyorwa musi weSvondo 3 (mushure mekuvhara mazai) kana Zuva 5. Masero anotumirwa kuongororwa. Kana mazai aya akaedzwa musi weSvondo 3, migumisiro inogona kudzoka mushure meSvondo 5. Kana zvakadaro, chero mazai nemigumisiro yakaisvonaka inogona kutaridzirwa kuendesa mberi. Mamwe mazai anokwanisa kuve akavharidzirwa kune rimwe denderedzwa.

Zvisinei, sezvataurwa pamusoro apa (muchikamu chebumbiro rinonzi embryo biopsy), Zuva 5 bhiopsy inogona kukurudzirwa kana kusarudzwa. Muchiitiko ichi, mazai aya anogadzirwa uye anobva apedzisira apora. Hapana mazai achaendeswa panguva yeVIVF panguva iyi. Pane kudaro, ivo vacharamba vari "pamusoro pechando" kusvikira zvinoguma kubva pakuongorora kwemajini kunodzoka.

Kana imwe nguva migumisiro iripo, kutora chero mazai ayo anotorwa achiendeswa, mukadzi wacho achatora mishonga yekudzivisa kuvharidza uye kugadzirira chibereko chekugadziriswa. Panguva yakakodzera, rimwe kana mazamu mashomanana achagadziriswa uye agadziriswa kuti adzokere.

Apo Zuva 5 rakasvibiswa uye mazaya embryo kuenderera mberi kunosarudzwa, nguva yekurapa inogona kupera kwemwedzi miviri kana mina (pamwe chete mwedzi unogona zororo / kurindira nguva.)

Ngozi dzePGD / PGS

IVF nePGS uye PGD inouya nematambudziko ose ehutano hweVIV.

Mukuwedzera kune ngozi idzodzo, ani zvake anofunga nezvePGD / PGS anodawo kunzwisisa izvi zvinowedzera dambudziko:

Kurarama hupenyu hunogona kunge hwakaderera kupfuura yevamwe vezera-vakafananidzwa nevezera rako. Ichi ndechokuti mamwe mazamu haazopona purogiramu uye vamwe (kana vose) vangazodzoka nemigumisiro yakaipa.
NeZuva 5 bhiopsy, kune ngozi shoma shoma yekufananidza twinning.
Mafungiro enhema uye zvakaipa zvisina kururama zvinogoneka. Mune mamwe mazwi, mazamu asina kukodzera anogona kuedza "zvakajairika," uye mazai ane utano anganganisa kuonekwa seasina kumira uye akarasikirwa. Nokuda kwehutano hwakanyanya, kune 2 muzana yehutachiwana hwemucheche kuwana chigumisiro chinowanzoitika kana chisina kujairika, uye ine 11 muzana yega yega inowanzokonzera zvirwere zvegenetic.
Kana mazai ose achidzoka nemigumisiro yakaipa, pangasava neanotakurisa.
Zvisingazivikanwi zvigumisiro zvingaitika. Iyo inozivikanwawo sembryos e-mosaic, iyi ndiyo apo dzimwe masero anoonekwa sechando chromosomally uye vamwe havakwanisi. Zvimwe zvidzidzo zvakaona kuti mazai emasikisi anogona kururamisa ivo pachavo uye anogona kutungamirira kumubereki ane utano hwakanaka uye mwana.
Kugadzirwa uye kusveta kunotevera kunogona kutungamirira pakurasikirwa kune dzimwe nzira mazai ane utano.
Mamwe mazai ane hutano ane hutano angasapona kusvikira Zuva rekutanga kutora mazai evha.
Nyuchi yezuva 3 mazamu angatungamirira kumucheche kumusungwa, apo imbryo inomira ichikura.
PGD / PGS haisi yeupenzi, uye mwana ane chirwere chegeneti kana chirwere chinogona kuguma. Kuedzwa kwepabonde nekuwedzera kwePGD / PGS inokurudzirwa kuvimbiswa kwekuwedzera.
Zvakanaka PGD / PGS uye kuongorora kwepabonde hazvirevi kuti mwana haazovhiringidzi nehutano hwepanyama kana hwemamwe marudzi.
Ngozi yekupererwa pamuviri inogona kunge yakaderera nevana vechidiki vePGS embryos, asi kune imwe nguva ingangova nengozi yekudzivirira pamuviri.
Kurindira zvikwereti uye kudiwa kuita zvisarudzo pamusoro pemabrosi nemigumisiro isina kukwana inogona kunge yakaoma mupfungwa.
Inyanzvi yekombiyuta yakatsva zvokuti hatinyatsozivi kuti inguva yakareba sei inogona kuva pavana vanoberekwa mushure meVF-PGD / PGS. Zvisinei, zvibereko zvekutanga zvinotarisa zvakanaka. Zvidzidzo zviduku zviviri zvakawana kuti vana ava havasi pangozi yekukurumidza kunonoka. Vavewo vane zviyero zvekuzvarwa zvakajairika.

Inguva ipi PGS / PGD Zvinodhura?

IVF yakato inodhura. Kuwedzera pamutengo wePGS kana PGD kunosimudzira mutengo wekutengo kunyange wakakwirira. Paavhareji, PGD / PGD inowedzera pakati pe $ 3,000 uye 7,000 kusvika kuVIV. Mari yako yehuwandu hweVIVF nePGS / PGD inogona kuva pakati pe $ 17,000 ne25,000.

Pamusoro peizvi, iwe unogona kubhadhara hove yechbrus transfer (FET). Izvi zvichava $ 3,000 kusvika ku5 000. Dzimwe nguva, varwere vanoda kuronga chirongwa cheFET kuitira pakarepo mushure mekunge IVF ishanduka. Nenzira iyi, nokukurumidza apo migumisiro yekuongorora maitiro ekudzoka inogona kudzoka, inogona kutumira chero mahara emhando dzisina kumira pasina kumirira imwe mwedzi.

Zvisinei, chinetso chinogona kuitika nenzira iyi ndechekuti kana pasina mahara ekuberekwa kuendesa mberi, mamwe emitengo yeFET ichave yakaparadzwa. Chero mishonga yekuberekwa inotorwa kunodzvinyirira kuvhuvhuta uye kugadzirira chibereko chekugadziriswa ichave yakatorwa pasina chikonzero.

Kumirira mwedzi unoverengeka kunogona kuoma mupfungwa, asi mari ingaita kuti iwedzere kunzwisisa. NePGD, iwe unogona kuva nemari kudarika kwekuita kurapa pachako pachako. PGD dzimwe nguva inoda kuongororwa kwemajeni emhuri, uye iyo mari haingabatanidzwi mumakirini ako ekuberekesa uye inogona kunge isina kuvharwa neishuwarisi.

Shoko Rinobva Kunyanya

Genetic screening yakabatsira mhuri dzine zvirwere zvepabonde kana chromosomal kutumira kune mukana wakanaka wekuva nehutano hwakanaka uye kudzivisa kudarika zvirwere zvinoparadza. Genetic screening yakabatsirawo vanachiremba kuti vawedzere kusarudzwa kwemazamu mumusarudzo imwe chete yembramu kuendesa maitiro.

Kunyangwe PGD / PGS inogona kuvandudza mararamiro ekuberekwa kwehupenyu kunze kweizvi mamiriro asina pachena. Inyanzvi iyi inenge ichiri itsva uye ichiramba ichichinja. Kushandisa PGS kuvandudza mararamiro ekuzvarwa patsva mu IVF apo teknolojia haina kunyatsoratidzwa inopesana.

Vamwe vanachiremba vanotaura kuti vanoona kubudirira kubudirira, asi vamwe vanobvunzurudza kana zvakakosha zvakakwana mari yakawedzerwa uye zvinetso. Vamwe vanofunga kuti inofanira kupiwa kune varwere vose veVIV; vamwe vanotenda kuti inofanira kupiwa kazhinji, mumamiriro ezvinhu chaiwo.

Zvinogoneka kuti PGS inogona kubatsira kudzivisa kutumira mazai angadai asina kuguma pakupererwa. Zvisinei, izvi hazvirevi kuti vaviri vacho havazozove nemuviri wehutano hwakanaka nehuwandu hwehuwandu hwekuvharidzirwa embryo (FET) kubva kune imwechete.

Semuenzaniso, ngatitaurirei kuti vaviri vanobatana nemamirosi matatu akasimba. Ngatiti ivo vanoita PGS uye vanoona maviri embryos aya akajairika. Imwe kana maviri inoshandiswa, uye ngatitaurire kuti pamuviri inowanikwa mune imwe kana mbiri. Iye zvino, ngatitii ivo vaviri vakaroorana vakasarudza kusaita PGS, uye zvinoitika kuendesa kutanga embryo ne chromosomal kusina kuwanikwa. Izvozvo zvinopera mukupererwa. Asi ivo vane imwe kana maviri mamwe mazai akamirira kuti asvibiswe uye adzirwe, uye anogona kunge akawana mwana ane utano kubva pane imwe yemambrus. (Munzvimbo dzakanakisisa mamiriro ezvinhu, hongu.)

Pari zvino, tsvakurudzo inotaura kuti matambudziko ekuzvarwa patsva anowirirana mumamiriro ezvinhu ose-uye pasina PGS. Asi kune manzwiro anokonzerwa nekuwana pfupa. PGS haina kubvisa kukanganisa kwekurasikirwa-kunyange kunoratidzika kuderedza ngozi iyo.

Iwe iwe chete uye chiremba wako chete unogona kusarudza kana IVF nePGD / PGS yakakodzera mhuri yako. Usati waita chisarudzo, iva nechokwadi chokuti unonzwisisa chikonzero nei chiremba wako achikurudzira izvi zvakabatsiridza tekinoloji yekuberekera iwe, iyo yose mari (kusanganisira cryopreservation uye FET zvidzidzo), uye zvingangova nengozi.

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> Practice Komiti yeSosaiti ye Rubatsiro Rwakabereka Dzidzo; Komiti Yedzimiro yeAmerican Society yekuberekwa Mishonga. "Preimplantation genetic testing: maitiro emakomiti ekudzidzira." Fertil Steril. 2008 Nov; 90 (5 Suppl): S136-43. doi: 10.1016 / j.fertnstert.2008.08.062.

> Schattman, Glenn L; Xu, Kangpu. Preimplantation genetic screening. UpToDate.com.

> Schattman, Glenn L. Preimplantation genetic diagnosis. UpToDate.com.

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