VaGnRH vanopikisa vane mishonga inopindwa mishonga inoshandiswa panguva yehutano hweVIV . Vanodzivisa kuvhara nguva isati yasvika, saka chiremba wako achakwanisa kudzorera mazai kubva mavha mavari asati asunungurwa uye "akarasika."
Usavhiringidza GnRH agonist - saLupron - nevarwi veGnRH. GnRH agonist inokonzera kuwedzera mune mahomoni ekuberekorora uye, shure kwemazuva mashomanana, yevhara mahomoni iwayo.
Kana ikashandiswa panguva yehutano hweVIV, inofanira kutanga kutanga kwemavhiki mashoma mushure mekunge chirwere cheVIV chichitanga.
VaGnRH vanopikisa havasi kuumba ichi chekutanga kupinda mahomoni. Inotanga mushure mokunge IVF yakatangira uye inogona kutorwa kamwe kana zuva nezuva kwemazuva mashoma. Nokuti dzinotorwa kwenguva shomanana, dzinokonzera madhara mashoma, kwenguva shomanana.
Nyaya inokosha! Hazviiti zvose zvinokonzerwa nemigumisiro uye njodzi dzakanyorwa pasi apa. Kana uri kutarisana nemigumisiro yakakomba, zviratidzo zvisingawanzoitiki, kana unonetseka nechikonzero chero chipi zvacho, taura nechiremba wako. Mashoko aya ari munyaya ino haaiti nzvimbo yekubvunzurudza nevhidhiyo.
Ndeapi Mishonga Inonzi GnRH Antagonists?
Kune mairi maviri anonzi GnRH anokonzera pamusika: ganirelix acetate uye cetrorelix acetate.
Mazita emagetsi eti ganirelix acetate anosanganisira Antagon, Ganirelix, uye Orgalutran.
Cetrotide ndiro zita rechirorelix acetate.
Iyi mishonga inotorwa nejoi. Mishonga inogona kusanganisira jekisi rimwe, kuisira kwezuva nezuva kwemazuva mazhinji, kana majekiseni asina kubatwa mazuva mashoma. Zvose zvinoenderana nehutano hwako hweVIV.
VaGnRH vanopikisa vashoma kudhura kupfuura GnRH agonists, asi mari yakawedzerwa haigoni kuita zvakakosha sezvo vanopikisa vanotorwa kwenguva shoma.
Uyewo, vamwe vakadzi vanofunga kuti zvishoma zvinokonzerwa nehuwandu hwekuwedzera mari.
Kunyange zvazvo vamwe vanachiremba vanobereka vanosarudza GnRH agonist nokuti vakagara vari kure, kutsvakurudza hakuna kuwanika mutsauko pakubata pamuviri kubudirira pakati pevaronist uye vanopikisana. Taura nachiremba wako kana iwe uchida kufunga vaGnRH vanopikisa pane GnRH agonist.
Migumisiro Yechirwere yeGnRH Antagonists
Zvose izvi serorelix acetate uye ganirelix acetate basa nekuvhara kukwanisa kwetambo yepituitary kukwanisa nekusunungura FSH neLH . Izvi zvinokonzera kushanda kwenguva pfupi, izvo zvinotungamirira kumigumisiro. Ndezvipi zvinokonzerwa nemigumisiro yaunogona kutarisana nayo inobva pakuti unozotora mishonga yakareba sei.
Zvose zvinokonzerwa ne cetrorelix acetate (Cetrotide) dzinosanganisira:
- Kusuruvara kwepamuviri uye unyoro (4.4% pazvinotorwa zuva nezuva, 2.1% kana zvichitorwa sechirwere chimwe chete)
- Musoro (1.3% newaini yezuva nezuva, 0% kana uchitorwa sewaiti imwe chete)
- Nausea (1.3% neruzhinji rwezuva, 1.1% neyero imwe chete)
Zvose zvinokonzerwa neinerelix acetate (Antagon, Ganirelix, Orgalutran) dzinosanganisira:
- Kusuruvara kwepamuviri nemaevari (4.8%)
- Musoro (3%)
- Vaginal ropa (1.8%)
- Injection site pain or bruising (1.1%)
- Nausea (1.1%)
- Dumbu recheche (1%)
Ngozi dzeGnRH Antagonists
Kufa kwekutora: Panguva yekudzidzira zvipatara, 3.7% yekubata pamuviri wakabatwa pakutora hainarelix acetate yakaguma mukufa kwe fetal, kana kuti ichiri kuberekwa.
Kunyangwe izvi zvakabatanidzwa nevarwi veGnRH zvakananga, kana kune dzimwe mishonga IVF, IVF pachayo, kana kuti kuberekwa, hazvizivikanwi.
Kukanganisa kwekuzvarwa : Ongororo dzakawana njodzi yakanyanya yepamusoro yekuremererwa kwepamuviri pakuberekwa kunowanikwa pakutora ganirelix acetate. Pasinei nokuti izvi zvakabatanidzwa nemishonga iyi, mamwe madhiragi eVF, IVF maitiro avo pachavo, kana kuti kuberekwa hazvizivikanwi.
Ovarian hyperstimulation syndrome (OHSS) : Inowanikwa muna 2.4% yevakadzi vari kurapwa nainirelix acetate. IHSS haina kukonzerwa nevashori veGnRH, asi nejonadotropins inotorwa panguva imwe chete.
Zvidzidzo zvakawana kuti njodzi yekuve neHSSSS inononoka nevanopikisa GnRN kana ichienzaniswa nekurapwa neGnRH agonists.
HSSSS yakanyanya inowanikwa muzasi pe1% yevarwere. Bvunza chiremba wako pakarepo kana iwe uchirutsira, chirwere chakakomba kana kurwadziwa kweplavic, kukurumidza kuwandisa, kana kuputika kukuru.
> Sources:
CETROTIDE cetrorelix (as acetate). Dhod Data Data. Yakapinda February 4, 2014. http://www.medsafe.govt.nz/profs/datasheet/c/Cetrotideinj.pdf
European and Middle East Orgalutran Study Group. "Kuenzaniswa kwekliniki yemugumisiro uchishandiswa neGnRH anopikisa inerelix kana kuti protocol yakareba yeGnRH agonist triptorelin yekudzivirira kusati kwasvika LH inosangana nevadzimai vari kukurudzirwa." Hum Reprod . 2001 Apr; 16 (4): 644-51. http://humrep.oxfordjournals.org/content/16/4/644.full?sid=3335d39c-68fd-455f-b948-e4ffa2a70b66
Ganirelix Acetate Injection. Drug Information Sheet. Merk. Yakapinda February 4, 2014. http://www.merck.com/product/usa/pi_circulars/g/ganirelix/ganirelix_pi.pdf
Ragni G, Vegetti W, Riccaboni A, Engl B, Brigante C, Crosignani PG. "Kufananidza kweGnRH agonist uye vanopikisa mukubatsira maitiro ekuberekorora kwevarwere vari pangozi yakawanda ye ovarian hyperstimulation syndrome." Hum Reprod . 2005 Sep; 20 (9): 2421-5. Epub 2005 Mbudzi 12. http://www.ncbi.nlm.nih.gov/pubmed/15890731