Chikonzero Nei Vamwe Masayendisiti Vasinganzwisisiki Sangano Riripo
Kuwedzera kwekutarisa kwakaiswa kune chimwe chinhu chinonzi MTHFR genetic mutation uye masangano ayo ane huwandu hwehutano husina kunaka, humwe huri hwakatsigirwa zvakasimba uye humwe hwahwo hunofungidzira zvakanyanya.
Mumakore achangobva kupfuura, mashoma masayendisiti akaratidza kuti kuchinja kwacho kunogona kunyatsotsanangura kuti sei vamwe vakadzi vakadzokera shure .
Kunyange zvazvo dzidziso yacho iri kure nekukwanisika, inounza muchivaraidza iyo iyo iyo genetics inogona kutamba mune zvisingaenzaniswi zvisingatauri, kana zvikamu.
Kutsanangura Mutemo weMTHFR
Mhedziso yeMTHFR inosakatika mumunhu wekodhi coding iyo inovhiringidza kukwanisa kwemuviri kubereka kweMTHFR enzyme. Inonzi MTHFR enzyme, uyewo, iyo yakakemikari inobudiswa nemuviri kuti inobatanidza zvakakwana folic acid (vitamini B9) .
Izvozvo zvinokonzerwa nekushaikwa kwe enzyme zvinogona kukonzera matambudziko akawanda. Iyo yakaipisisa inowanzoitika kune vanhu vakagara nhaka MTHFR mutation kubva kuvabereki vose (chimiro chinonzi homozygosity), nepo avo vanogara nhaka imwe geni (heterozygosity) vangave vane zvinetso zvishomanana, kana zvimwe, zvinoshamisa. Kuva nechirwere cheMTHFR hakurevi kuti uchawana humwe hutano; zvinongowedzera ngozi yako yose.
Zvimwe zvezvinetso zvehutano zvinowanzobatana neMTHFR mutations dzinosanganisira:
- Homocystinuria, chirwere umo muviri haukwanise kushanda homocysteine, kazhinji huchitungamirira kumatambudziko eziso, kusina ropa kuvhara ropa, marwadzo asina kukodzera, uye zvinetso zvekuziva
- Anencephaly , chirwere chekuberekwa chinoratidzika kuti hachina kana zvikamu zvisina kuumbwa zveuropi kana kede
- Spina bifida, kusina kukwana kwefupa kumativi ose emutsara
- Kurasikirwa kwekunzwa kuchema kunzwa
Zvimwe zvidzidzo zvakabatanidza kuchinja kweMTHFR kune chirwere chepfungwa, kurohwa, hypertension, preeclampsia (high blood pressure during pregnancy), glaucoma, zvirwere zvepfungwa, uye mamwe marudzi ekenza. Zvizhinji zvezviongorori izvi zvakave zvakasanganiswa. pamwe neshamwari dzakawanikwa mune dzimwe asi kwete mune vamwe.
Zvose zvinotaurirwa, MTHFR genetic mutations inowanzojairika, uye inenge hafu yehuwandu hweUnited States inogona kunge yakanyanya heterozygous yekuchinja.
MTHFR uye Kuparara Kwemhirizhonga
Nokuti huchapupu huripo huno husina kutsigirwa, kune masayendisiti akawanda anopesana nepfungwa yokuti kushandiswa kwemasimba uye kuchinja kweMTHFR kwakafanana. Avo vanotsigira pfungwa iyi vanoita izvi zvichienderana nekuwedzera kwechiitiko chekuparadzana pakati pevakadzi vane zvimwe zvakasiyana-siyana zvinonzi MTHFR C677T mutation.
Chinokosha pakukakavadzana ndiyo iyo inonzi homocysteine inofanirwa kutamba. Homocysteine is amino acid inowanzobudiswa nemuviri unobatsira mu metabolism B mavitamini. Pamberi pekuchinja kwe C677T, homocysteine haigoni kuve yakashandurwa zvakare uye inotanga kuunganidzwa muropa. Apo izvi zvinenge zvichiitika, zvinogona kutungamirira kune chirwere chinoputika chinonzi homocysteinemia iyo inonzi inozviisa pangozi yegononary artery disease.
Vaya vanotsigira chidzidzo chacho vakaratidza kuti homocysteinemia inogona kukonzera kuumbwa kwemakumbo maduku eropa anovhara kubuda kwezvokudya kune placenta, kunyanya kushaya nzara mucheche uye kuchikonzera kubvisa pamuviri pakarepo . Iyo inyanzvi yakakakavara uye imwe iyo iyo chaizvoizvo haisi humwe uchapupu hwakaoma.
Nezvo izvo zvataurwa, vakadzi vazhinji vane kupererwa kwepamuviri kwekare vanoedza kuonekwa zvakanaka kune mutemo weMTHFR. Sezvakadaro, vamwe vanachiremba vakabvumidza kushandiswa kwemishonga inopesana-clotting yakadai se heparin uye pasi-dose aspirin kuderedza dambudziko rekuvhara ropa. Vamwe vanokurudzira maitiro akadai e folic acid uye mamwe mavitamini B, achitenda izvozvo zvinogona kupa homocysteine chinangwa uye nzira inofanira kubviswa kubva mumuviri.
Kunyange zvazvo pasina humwe uchapupu hwokuti chimwe chezviyero izvi chinoderedza dambudziko rekusununguka kwepamuviri, panewo uchapupu hushoma hwekuratidza kuti huchaita chero kukuvadza kupi zvako.
Shoko Rinobva Kunyanya
Nhaurirano inoramba ichitsamwiswa pamusoro pemigumisiro yeMTHFR mutation pamubereki, gore ra2013 rinokurudzirwa kubva kuAmerican College of Obstetricians uye Gynecologist vakataura kuti uchapupu huno maererano nehutano huri "hushoma" kana "husingaenderani" uye hunorayirwa kusashandisa mTHFR genetic kuongorora kana kutsanya homocysteine kuedza sechikamu chekuongorora mushure mekuberekwa .
> Sources:
> American College yeVadzidzi uye Gynecologists. "ACOG Practice Bulletin Nhamba 138: Thrombophilia inoberekwa muhutano." Obstet Gynecol. 2013; 122 (3): 706-17. DOI: 10.1097 / 01.AOG.0000433981.36184.4e.
> Chen, M ;; Yang, X; uye Lu, M. "Methylenetetrahydrofolate reductase gemu polymorphisms uye kukanganisa kuberekwa pamuviri muChina: kuongorora nekugadzirisa uye meta-analysis." Arch Gynecol Chibvumirano . 2016 Feb; 293 (2): 283-90. DOI: 10.1007 / s00404-015-3894-8.