Chii chinonzi GnRH, Iyo Inoshanda Sei, uye Inorapwa neGnRH
GnRH inotsanangurwa ne gonadotropin-releasing hormone. Iyi hormone inosunungurwa ne hypothalamus muuropi.
GnRH inobata pane zvinogamuchirwa munharaunda yepteritary gland. GnRH inoratidza gland pituitary kuti ibudise gonadotropin hormone follicle-stimulating hormone (FSH) uye luteinizing hormone ( LH ).
FSH uye LH zvino shandisa mazamu mumadzimai uye pamayeso evanhu.
Dzinotanga mazai ekukura uye kuvhara mazai, uye, mumarume, anokonzera ma testes kuti akure uye kubereka mbeu.
FSH neRH zvinokurudzira mavhai uye ma testes kuti vasunungure mahomoni avo.
- Mune mazaiyo, estrogen, progesterone, uye testosterone zvinogadzirwa.
- Muma testes, testosterone uye estrogen inosunungurwa.
GnRH inosunungurwa mumapulisa uye kwete nekuenderera mberi.
Mune varume, izvi zvinotakura zvinouya zvakakwana.
Madzimai, kuwandisa kwemafupa kunosiyana zvichienderana nekuti muviri uri kupi panguva yekuenda kumwedzi. Somuenzaniso, nguva isati yasvika, maGnRH mapepa anowanzoitika.
Mamwe Mazita eGnRH
- Luteinizing hormone-releasing hormone (LHRH)
- Luteinising-hormone-kurega hormone
- Luliberin (mushonga wepachivande unoita seGnRH mumuviri)
- Gonadorelin (mushonga unopinza unofanana neGnRH mumuviri)
Kuedzwa NaGonadorelin
Gonadorelin imishonga inoita sehomoni GnRH mumuviri.
Inogona kushandiswa mukuongororwa kwechiremba kana sekurapa kwekunonoka pakuyaruka kana kusabereka.
Kuedza kunowanzobatanidza kugamuchira majekiseni ehomoni iyi pane imwe nguva.
Kutanga, iwe uchange uine kuteura ropa, usati wajowa nehomoni.
Zvadaro, pane imwe nguva, jekesheni yegonadorelin iri pasi peganda kusvika mumafuta.
Zvadaro, mushure memazuva akawanda, iwe uchava neropa rako rakawedzerwa zvakare.
Iyi nzira - jira rinotevedzwa neropa rinodhonza - richaenderera mberi. Zvigumisiro zvichazoongororwa mubhiiyo.
Uyu muedzo unogona kuitika kuvana vane kuchetera kuberekwa kana vanhu vakuru vane kusafungidzirwa kusina kufanana kwemasimoni.
Kurapa neGonadorelin kuburikidza neLutrepulse pump
Vakadzi vasiri ovulating vanogona kurapwa ne gonadorelin kuburikidza nepombi yeLutrepulse. Izvi zvinoitwa kana kushayikwa kweGnRH ndicho chikonzero chekuzodza.
Varume vasiri kupa mbeu inogonawo kurapwa nePutopupa pombi.
Pombi inopa muyero wakayerwa maminitsi makumi mapfumbamwe nemapfumbamwe kwemavhiki.
Mushure mokunge mushonga watanga, mumadzimai, zvinowanzotora mavhiki maviri kusvika matatu kuti ovulation zviitike. Mushure memhevulation, kurapwa kunowanzoenderera kune imwe vhiki mbiri kuburikidza nechikamu chekateal.
GnRH-a Are GnRH Agonist uye Antagonists
Munguva yekurapa kweVIV , chiremba wako wekubereka unoda kudzora chirwere chekurera. Kana zvisina kudaro, mazai anogona kukonzerwa kare kare. Havazokwanisi kudzorerwa uye kubudiswa mubazi re embryology kana izvi zvikaitika.
Ichi ndicho chikonzero iwe unogona kutora GnRH agonist kana GnRH kupikisa.
Mese yemishonga inobereka hurumende inonzi menopausal state.
Kusiyana pakati pezvinodhaka ndeyekuti GnRH agonist inotanga kubudisa kuwedzera mune mahomoni FSH neHH uye zvino vanomira. Mupikisi weGnRH haaiti kuti chigamba ichocho chivepo.
Munguva yeVIV, iwe pachako ugozvipa majekiseni emahomoni FSH neHH kusimudzira mavhai mazai kubudisa mazai.
GnRH agonist inosanganisira:
- Lupron
- Synarel
- Suprecur
- Zoladex
VaGnRH vanopikisa vanosanganisira:
- Antagon
- Ganirelix
- Orgalutran
- Cetrotide
GnRH agonist ingashandiswa zvakare kurapa endometriosis uye fibroids.
> Sources:
> Gonadorelin (Intravenous route, Injecting route). Micromedex Inonyatsotsanangurwa Zvinodhaka Mishonga kune Mutengi [Indaneti]. PubMed Health.
> Gonadotropin-Releasing Hormone. Iwe neHormoni dzako. Society of Endocrinology.
> Mishonga yeIn Inducing Ovulation: Mutungamiri wevarwere. American Society of Reproductive Medicine.